There was also no difference between the percentages of IL-21-producing CD134+CD4+ T-cells in SLE patients with lupus nephritis as compared to patients without lupus nephritis (12.5 ± 12.7% vs. 11.6 ± 10.6%; p = 0.89). The gene discussed is TNFRSF4; the disease is systemic lupus erythematosus.