The percentages of IFN-γ-producing CD134+CD4+ T-cells were significantly increased in SLE patients with lupus nephritis as compared to patients without lupus nephritis (25.4 ± 11.4% vs. 15.0 ± 10.1%; p = 0.007, Fig. 4). The gene discussed is TNFRSF4; the disease is systemic lupus erythematosus.