SOAT1 and mucosal melanoma: For instance, a kinome-wide RNA interference, exome sequencing and a drug screen identified activation of the PI3K, JAK/STAT and MAPK pathway and modulators of histone modification as mechanisms of acquired resistance and inhibitors against different key molecules in these pathways in breast cancer, myeloproliferative neoplasia, mucosal melanomas and leukemia overcame this resistance [18, 19, 53–55].