By mimicking the effects of viral infection (by treatment with the pIpC, a TLR3 agonist, or by Ifnb1 treatment) or other stimulation (by treatment with LPS, a TLR4 agonist), we did not find any activation of the Atp1b3 gene in both WT and Trim33−/− BMDM (Additional file 5: Figure S5f), suggesting that ATP1B3 functions could be restricted to specific viral infections. The gene discussed is ATP1B3; the disease is viral infectious disease.