The reduction of the ESCC volume in the shHERG1 #1 and shHERG1 #2 mice was accompanied by downregulation of TXNDC5, cyclin D1, vimentin, and fibronectin expression and upregulation of p21 and E-cadherin expression (Fig. 7d). Here, TXNDC5 is linked to esophageal squamous cell carcinoma.