LRRK2 and Parkinson disease: Other autosomal dominant mutations are found in the Leucine rich repeat Kinase 2 (LRRK2) domain, accounting for 4% of familial PD [12], in the vascular protein sorting 35 (VPS35) gene [13], accounting for 1% of familial PD and in the CHCHD2 [14] and eIF4G1 [15] genes.