BRAF and neoplasm: In addition, Laura et al. [36] found that height is a stronger risk factor for CRCs with BRAF mutations or MSI, suggesting that molecular pathological epidemiology (MPE) demonstrates the strengths of interdisciplinary integration to study CRC because more and more evidence indicates that diet, smoking, lifestyle, and the microbiome may influence the genome, epigenome, transcriptome, proteome, and metabolome of tumor [37].