MLH1 and Lynch syndrome: To test this hypothesis, we extracted the methylation probes specific to MLH1 and BRAF (V600E) status and found that MLH1 hypermethylation was always accompanied by BRAF mutations in both MSI-H1 and MSI-H2, indicating that MSI-H1 did not correspond to Lynch syndrome, because MLH1 deficiency and BRAF mutations rarely occur simultaneously in this disorder.