These results [19], together with the ability of α-synuclein to bind lipids and the abundance of lipids in Lewy bodies [17, 82], raise the possibilities that α-synuclein could interact with certain types of lipids under pathological conditions promoting its oligomerization and further aggregation (Fig. 2e), and that lipid perturbations are potentially a primary driver of PD and aging pathology. Here, SNCA is linked to Parkinson disease.