In Drosophila and rat models of α-synucleinopathy, Nedd4 overexpression prevents neuronal dysfunction and pathology [133], and NAB2, an activator of the Nedd4 pathway, rescues α-synuclein toxicity in vitro in both yeast and human neuron α-synucleinopathy models [134]. This evidence concerns the gene NAB2 and synucleinopathy.