CCR1 and endothelial dysfunction: Furthermore, migration of RECs provoked by MIP1γ was blocked by CCR1 antagonist J-113863 [36] (Fig. 6c), and loss of monolayer integrity and leakage of FITC-dextran by MIP1γ were reversed by J-113863 (Fig. 6d & e), Indicating that blocking MIP1γ/CCR1 pathway in endothelial cells may prevent the inflammatory macrophage-induced endothelial dysfunction.