IL6 and diabetes mellitus: This is evidenced by a follow up study showing graded increases of high sensitive CRP (hs-CRP) and IL-6 to be associated with the increased risk of developing diabetes; those in the highest quartile of baseline plasma hsCRP had 5 times greater risk than those in the lowest quartile (HR = 5.13;95%CI 2.6–10.1), for those in the highest quartile of IL-6 rates were 3 times greater than those in the lowest quartile (HR 3.45;95% CI 1.91–6.23) [12].