EGFR and gastric cancer: 6 in Materials and Methods). EGFR stands out as the most significant gene and its p-value, being1.5 × 10− 23, is at least five orders of magnitude smaller than all other genes (Fig. 5b). EGFR as a predictive biomarker for cetuximab on gastric cancer is supported by a phase 2 clinical trial [25] and a phase 3 clinical trial with data re-interpretation (Additional file 1: Figure S11) [26].