In summary, the virulence factors of E. faecium were mainly adhesion proteins that mediate adherence to host tissues, including efaA (an endocarditis specific antigen, present in 160 isolates), acm (a collagen adhesin precursor, present in 93 isolates), ecbA (a collagen binding MSCRAMM, present in 42 isolates), ebp pili (endocarditis- and biofilm-associated pili, present in 14 isolates), and esp (an enterococcal surface protein, present in 9 isolates). The gene discussed is EBP; the disease is endocarditis.