Analyses stratified by baseline characteristics among participants with or without coronary heart disease, with or without diabetes mellitus, receiving atorvastatin 80 mg or 20 mg daily, and male or female did not identify an impact of ADCY9 genotype on the proportional reduction in major vascular events (all allelic and genotypic interaction P values of >0.05). This evidence concerns the gene ADCY9 and diabetes mellitus.