Accordingly, it has lately been discovered that inhibition of C5a signaling with PEGylated C5a blocking L-aptamer AON-D21 (formerly NOX-D21), in combination with PD-1/PD-L1 inhibition, inhibits tumor growth more potently than PD-1/PD-L1 inhibition alone [103]. This evidence concerns the gene C5 and neoplasm.