BRAF and recessive dystrophic epidermolysis bullosa: Cumulative solar UV radiation is the primary risk factor for cSCC [27,28] and additional risk factors include male sex, advanced age, fair skin, immunosuppression [18,20,29], chronic cutaneous ulceration, HPV infection, smoking, chronic lymphocytic leukemia, non-Hodgkin lymphoma, BRAF inhibitor medication, chronic cutaneous inflammation, and hereditary blistering skin disorders, such as recessive dystrophic epidermolysis bullosa (RDEB) [1,18,25,30,31,32].