Differential gene expression analysis of tumor samples removed from EPZ-011989-treated and untreated mice revealed that, among the 5521 genes with a significant differential expression (according to false discovery rate, FDR < 0.05), 3410 genes (62%) were up-regulated and 2111 genes (38%) were down-regulated, respectively (Figure 3, Table S3), thus indicating a generally increased transcriptional activity in treated tumors, consistent with EZH2 inhibition. Here, EZH2 is linked to neoplasm.