CGM097 and HDM-201 in combination with FLT3 inhibitors, midostaurin, BKM120 (buparlisib), GDC-0941 (pictilisib), BYL719 (alpelisib) and ASP2215 (gilterinib) also exhibited a moderate to strong synergistic response in AML cell lines [44]. Here, FLT3 is linked to acute myeloid leukemia.