Interestingly, concerning meiotic kinase MOS and quite in accord with our current data, Vitale et al [90] found in colon cancer p53-null cells treated with nocodazole that multipolar mitosis in induced transient tetraploidy cells was dependent on upregulation of this kinase, which inhibited the coalescence of supernumerary centrosomes and finally favored selection of less aneuploid progeny. This evidence concerns the gene TP53 and colonic neoplasm.