We further identified the down-regulation of miR-190a and miR-214 as an epigenetic mechanism induced by MGO, contributing to endothelial insulin-resistance through the regulation of the kinase kirsten rat sarcoma viral oncogene homolog (KRAS) [157] and the Akt phosphatase PH Domain And Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) [158], respectively. The gene discussed is AKT1; the disease is Insulin resistance.