Given the central role of LSD1 for sensing and integrating energetic information into the epigenome [18,19,20,21,22,23,24,25,53,54], the LSD1-targeted inhibitory activity of oleacein might represent a novel mechanism through which EVOO phenolics impact the crosstalk between the metabolism and epigenetic gene regulation to exert health-promoting effects in a wide variety of human diseases, including obesity-associated diseases, neurological disorders, and cancer (Figure 6). The gene discussed is KDM1A; the disease is cancer.