Interestingly, a recent study conducted in a SH-SY5Y cell line, in brain cortical region samples from patients with AD, and in transgenic APPswe/PS1dE9 mice which develop AD, demonstrated an increase in δPKC activity and expression that regulates β-site APP-cleaving enzyme 1 (BACE1) expression, thereby enhancing Aβ production. The gene discussed is BACE1; the disease is Alzheimer disease.