The MAPK signaling pathway is associated with progressive dysfunction in multiple neurodegenerative diseases and mitochondrial-mediated apoptosis; hence, we investigated the protective effect of vasicinone on members of the paraquat-induced MAPK pathway including JNK, ERK, c-JUN and p38 in SH-SY5Y cells. Here, MAPK8 is linked to neurodegenerative disease.