CD274 and cancer: While a balanced PD-1/PD-L1 interaction is a prerequisite for maintaining the normal T-cell response and assuring normal cell survival, overexpressed PD-L1 on cancer cells in the tumor microenvironment react with the PD-1 expressed on T cells and induce T-cell apoptosis, thereby facilitating tumor survival, progression, and evasion of the host tumor immune surveillance system [4,7,9].