Moreover, targeting macrophages by blocking CSF-1/CSF-1R decreased fibrosis at the primary tumour site of the autochthonous LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre mice (KPC) mouse model of pancreatic cancer [79]. This evidence concerns the gene CSF1R and familial pancreatic carcinoma.