CDKN1A and breast cancer: In this case, cotreatment with doxorubicin plus melatonin further increased the levels of CDKN1A. Therefore, adipocytes promote breast cancer cells adquisition of a more aggressive phenotype and doxorubicin treatment contributes to stimulate the EMT processes, whereas melatonin, at physiological concentrations, protects against TWIST1-mediated EMT.