DRAK1 is overexpressed and localized in the cytoplasm in head and neck squamous cell carcinomas (HNSCC) and negatively regulates the tumor suppressor function of TGF-β by binding to Smad3 which is required for Transforming Growth Factor Beta (TGF-β) function [23]. The gene discussed is TGFB1; the disease is head and neck squamous cell carcinoma.