GPT and hyperhomocysteinemia: Yefsah-Idres et al. [148] showed that rats with a diet high in methionine content had abnormal histological features accompanied by an increase in the levels of serum homocysteine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), as well as MDA hepatic and a decrease in the activities of cystathionine-β-synthase (CBS) and S-adenosyl-homocysteine hydrolase, indicating that lycopene supplementation reversed hyperhomocysteinemia (related to oxidative stress), providing additional evidence of the hepatoprotective effects of lycopene.