In the metastatic melanoma cell line UACC 903, the first study carried out by Kuzu et al. indicated that leelamine oil dissolved in dimethyl sulfoxide (DMSO) caused cholesterol accumulation and modified subcellular cholesterol localization, combined with an alteration in the members of the RTK–AKT/STAT3/MAPK signaling cascades (Erk, CREB, and RPS6KB1 (p70S6K), as well as activation of the STAT3 pathway, and phosphorylation of EIF4EBP1 (4E-BP1) was attenuated post-treatment), and the Akt/mTOR cascade was also inhibited. Here, RPS6KB1 is linked to melanoma.