STAT3 and cancer: When trapped in the lysosome, and thus not available for cellular processes, autophagic flux and receptor-mediated endocytosis are inhibited [62,63], which is also associated with the inhibition of receptor tyrosine kinases RTK signaling pathways, which can suppress the activation of the downstream PI3K/AKT, STAT3, and MAPK signaling cascades [4,28] that are responsible for cancer progression.