In addition to its impact on HO-1, IR-AKI also reduces the activity of antioxidant enzymes that scavenge ROS, including superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), and glutathione peroxidase (GPX), in post-ischemic kidney tissue [65]. The gene discussed is CAT; the disease is acute kidney injury.