Although evidences obtained in a model of severe Ang II-dependent hypertension strongly support the contention that EMT contributes to TIF, which is the major determinant of ESRD, likely via the activation of the AT1 and ETB receptors, it remains debated if EMT contributes to TIF in other forms of nephropathy, which are characterized by less prominent TIF. The gene discussed is AGT; the disease is hypertensive disorder.