Interestingly, in this model, TIF was also prevented by bosentan, a mixed ETA-ETB endothelin receptor antagonist, but worsened by BMS-182874, a selective ETA receptor antagonist, suggesting a key role of endothelin-1 (ET-1) acting via the ETB receptor subtype in triggering renal fibrosis [8]. Here, EDN1 is linked to renal fibrosis.