Down-regulation of CerS2 in SMS-KCNR neuroblastoma cells causes decrease in VLC Cer d18:1/24:0 and 24:1 and increase in LC Cer d18:1/14:0 and 16:0, accompanied with activation of the unfolded protein response (UPR), induction of autophagy and growth arrest, but not apoptosis [87]. Here, CBLN1 is linked to neuroblastoma.