CBLN1 and breast carcinoma: Interestingly, it was shown in MCF7 breast carcinoma cells that IL-1β induced up-regulation of S-SMase secretion and increased the selective production of Cer d18:1/16:0 and d18:0/16:0, whereas higher L-SMase activity was associated with a selective increase in VLC ceramides such as Cer d18:1/26:1, suggesting distinct metabolic roles for each acid SMase [85].