Based on (i) the clinical signs of toxicity in mice, (ii) the mode of action of PnTXs as nAChR competitive antagonists, and (iii) knowledge of drugs and natural toxins with PnTX-related pharmacology, potential symptoms in humans are proposed here: Muscle weakness (myasthenic-like syndrome), dyspnea, anticholinergic syndrome, dysautonomia, pyramidal syndrome, and seizures. The gene discussed is CHRNA4; the disease is dysautonomia.