PF4 and Hepatic fibrosis: One of the most abundantly present chemokines in platelet α-granules is chemokine (C-X-C motif) ligand 4 (CXCL4), which was shown to mediate liver fibrosis in vitro and in vivo by promoting HSC proliferation, migration, and signaling and by playing an active role in the intrahepatic inflammatory response.