Furthermore, inhibition of CCR1 decreased ERK activation and increased expression of osterix and osteocalcin, when in the presence of CCL3, suggesting CCL3 is an important regulator of osteoblast and osteoclast function, leading to the uncoupling of osteoblast and osteoclast homeostasis in multiple myeloma [175]. Here, CCR1 is linked to plasma cell myeloma.