In another example, Vicent et al. determined that bone resorption as driven by TGF-beta, anchorage-dependent factors including melanoma cell adhesion molecule (MCAM) and Sushi domain-containing protein 5 (SUSD5), and protein kinase D3 (PRKD3), a protein kinase that modulates the activity of matrix metalloproteinases during ECM remodeling [179], all promoted increased bone metastatic lung cancer colonization and growth [180]. Here, SUSD5 is linked to melanoma.