There are two isoforms of FGF-2: Low molecular weight FGF-2 (18 kDa), which is beneficial for an adaptive trophic response after MI [21]; while high molecular weight FGF-2 (20–34 kDa) is pro-hypertrophic and pro-apoptotic leading to maladaptive remodeling [22]. This evidence concerns the gene FGF2 and myocardial infarction.