SRC and cancer: In PDAC specifically, examination of multidimensional publically available cancer genomics datasets (TCGA, PanCan Atlas and QCMG cohorts) revealed that Src mutations occur at a frequency of less than 2% (Fig. 2B) 114, 115, indicating that aberrant intratumoural Src activity occurs through constitutive activation of Src, or by changes in the levels of regulators of Src and amplification of downstream signalling pathways 113, 116, 117, 118.