Given the importance of the integrin/Src/FAK signalling in diverse cancer types, significant research has also gone into targeting molecules upstream of Src, including integrins, which critically modulates ECM mechanics and cytoskeleton stability, stellate cell activation 226, cancer cell survival and angiogenesis 59 and most recently, production of tumour‐promoting cytokines and chemokines 227. The gene discussed is PTK2; the disease is cancer.