Synergy has previously been shown between a MEK‐inhibitor and PI3K/mTOR inhibitor in a lung cancer model, where inhibition of MEK/ERK was shown to stabilise BIM, and PI3K/AKT inhibition upregulated PUMA via FOXO, all of which are key mediators of apoptosis 215, 216. This evidence concerns the gene MAP2K7 and lung cancer.