In PDAC specifically, overexpression of integrin ανβ3/ανβ6 has been previously shown to associate with poor survival of patients as well as lymph node metastasis 59, 72, and recent findings indicate that the stromal localisation and levels of active α5β1‐integrin and FAK can identify two readily distinguishable desmoplastic phenotypes in pancreatic cancer. Here, PTK2 is linked to familial pancreatic carcinoma.