AKT1 and cancer: In addition to SRC, the integrin–focal adhesion signalling‐mediated modulation of ECM mechanics and cytoskeleton stability involves several important sensor proteins that are also frequently deregulated in cancer, including integrins, FAK and downstream Akt/PI 3‐kinase, LIM kinase, and Rho/ROCK activation 59, 60, 61, 62 (Fig. 1).