The TCGA cluster 5 (CEBPA mutated, Figure 5C) and its corresponding cluster on the Hemap AML map (refer to Figure 5A and Supplementary Figure S4B) were significantly associated with S-adenosylmethionine (SAM)-dependent methyltransferase activity (Figure 5D, hypergeometric test adjusted P-values 5.6e-05 and 1.5e-26, respectively). This evidence concerns the gene CEBPA and acute myeloid leukemia.