CYP51A1 and Chagas disease: TCMDC-143620 was found to be a potent inhibitor (IC50 = 79 nM) of T. cruzi sterol 14-α demethylase (CYP51) enzyme, which is involved in the ergosterol biosynthesis pathway and was considered until recent years as a promissory therapeutic target for Chagas disease [38, 39].