In this context, it is plausible that the high levels of BCDIN3D observed in aggressive breast cancers [5, 27] could decrease the levels of tRNAHis 3’ fragments to promote the mobility of these transposable elements and to enhance genomic evolution, which is a driving force promoting metastasis and drug resistance of cancer cells [30]. The gene discussed is BCDIN3D; the disease is breast carcinoma.