A previous study has shown in Alzheimer disease model mice that chronic fyn inhibition with AZD0530 treatment restores memory function and markers of synaptic density (PSD-95 and SV2a) in the dentate gyrus of the hippocampus induced by APP/PS1 transgenes.27 AZD0530 treatment may have a more focal effect on medial temporal lobe structure and function. The gene discussed is DLG4; the disease is early-onset autosomal dominant Alzheimer disease.