CYBB and neurodegenerative disease: The clinical significance of Nox2 activation in aging-related oxidative damage of human brain microvascular vessels and neurons was examined using postmortem human midbrain tissues (including the hippocampus and VTA) of young (25–38 years old), middle-aged (45–56 years old), and elderly (61–85 years old) adults without diagnosed neurodegenerative diseases, obtained from the UK Medical Research Council (MRC) tissue bank.