TLR4 and cardiovascular disorder: Likewise, SNPs in these regions of TLR4 have also been linked to an increased incidence of several diseases such as colon (Semlali et al., 2016), breast (Theodoropoulos et al., 2012), prostate, cervical cancer (2011), and cardiovascular disease (Eisler et al., 2011; Liu et al., 2015).