COX‐2 modulates pro‐inflammatory chemokines expression, influences cell proliferation and functions.5, 6, 7 COX‐2 was normally undetectable in most human tissues, but it could be rapidly induced in response to inflammatory stimuli, such as lipopolysaccharide (LPS) or angiotensin II (Ang II).8, 9 The expression of COX‐2 is well‐characterized in chronic inflammatory disorders, such as atherosclerosis.10 Genetic knockout of COX‐2 resulted in significant attenuation of acute inflammation corresponding with decreased PGE2 levels.11 The gene discussed is AGT; the disease is atherosclerosis.