TGFBR2 and neoplasm: At the end of the experiment (day 48), the average of tumor volumes of TGFBR2 mutants, G253V and E290K, was 6.9‐ and 8.8‐fold, respectively, larger than that of WT TGFBR2, indicating that TGFBR2 mutants promote tumor growth (Figure 5D).