Sequence analysis showed that the residues altered by the two mutations are conserved among the members of the TGF‐β receptor family, and thus may be functionally and evolutionarily important.37 Downregulation of TGF‐β signaling by miR‐93‐targeting TGFBR238 and by TNFRSF19 interaction with TGF‐β receptor I39 has been reported in NPC to counteract growth inhibition mediated by TGF‐β. This evidence concerns the gene TGFB1 and nasopharyngeal carcinoma.