In conclusion, we confirmed that PB2 inhibited the Hh signalling pathway and therefore down‐regulated the transcription of VEGF‐A, HIF‐1α, α‐SMA, Col‐1 and TGF‐β1 in HSCs to suppress activation, ECM production and angiogenesis, thus reversing the progression of liver fibrosis. Here, TGFB1 is linked to Hepatic fibrosis.