EGF and Hepatic fibrosis: Liver fibrosis is characterized by the over‐deposition of ECM, and the activation of HSCs by TGF‐β1, PDGF and EGF is the key link to the pathogenesis of liver fibrosis.5, 43 In the normal liver, HSCs maintain the production and degradation of ECM to maintain the balance of ECM deposition; however, in liver fibrosis the excessive activation of qHSCs to aHSCs contributes to the over‐deposition of ECM, especially collagen.3, 4 The results in Figure 2 showed that the expression of Col‐1 is significantly inhibited by PB2, which further confirmed the protective effect of PB2 on liver fibrosis.