In conclusion, we confirmed that PB2 inhibited the Hh signalling pathway and therefore down‐regulated the transcription of VEGF‐A, HIF‐1α, α‐SMA, Col‐1 and TGF‐β1 in HSCs to suppress activation, ECM production and angiogenesis, thus reversing the progression of liver fibrosis. The gene discussed is ACTA1; the disease is Hepatic fibrosis.