In consistence with our current findings, AKT and ERK1/2 activation was previously shown to develop in the diabetic retina,21, 22 which also expressed both galectin‐1 and IL‐1β.4, 5 Taken together, galectin‐1/LGALS1 expression in Müller glial cells proved to be regulated by AP‐1‐driven enhancer following diabetes‐related inflammatory signalling. This evidence concerns the gene IL1B and diabetes mellitus.