The results showed that Hep‐2 (Figure 3A,C) and AMC‐HN‐8 cells (Figure 3B,D) transfected with MEG3 plasmid displayed a higher apoptosis rate as compared with cells transfected with empty vector, which suggesting that the apoptosis of laryngeal cancer cells was induced by up‐regulation of MEG3. The gene discussed is MEG3; the disease is laryngeal carcinoma.