Maternally expressed gene 3 is initially found to be a growth suppressor in human cancer cells including HeLa, MCF‐7 and H4.11 Growing evidence has also demonstrated that MEG3 characterizes as a tumour suppressor in different types of cancer as evidence that overexpression of MEG3 could suppress the proliferation and induce apoptosis of cancer cells.14, 17, 18, 19, 20, 21, 22, 23, 24, 25 However, little is known about the role of MEG3 in laryngeal cancer up to date. This evidence concerns the gene MEG3 and laryngeal carcinoma.