It is very likely that which scenario occurs strongly depends on cellular conditions and pathological settings.16, 17, 49 Accordingly, under the conditions of this study, it can be postulated that the infarcted zone of HF is characterized by pro‐inflammatory TNF and IL‐1β elevation alongside signalling of necroptosis execution, while the alterations in non‐infarcted tissue with absenting p‐MLKL, and thereby exclusion of necroptosis, can rather be associated with solely inflammatory processes linking pSer229‐RIP3 and inflammatory cytokines. The gene discussed is MLKL; the disease is hydrops fetalis.