CEACAM5 and neoplasm: Over the past few decades, a number of prognostic factors for EC have been identified, including tumor length, vessel invasion, lymph node status (N stage), depth of invasion (T stage), TNM stage and other serum biomarkers, such as squamus cell carcinoma antigen (SCCA) and carcinoembryonic antigen (CEA) (Peyre et al., 2008; Wijnhoven et al., 2007; Feng, Huang & Zhao, 2013).