In another recent report, immunological depletion of CLEC-2 in mice using the anti-CLEC-2 mAb 2A2B10 suppressed haematogenous metastasis and thrombus formation of the PDPN-positive mouse melanoma cell B16F10, without inducing any significant bleeding.101 Further investigations are needed to evaluate therapies targeting PDPN in mitigating the thrombotic risk in pancreatic cancer. Here, PDPN is linked to melanoma.