PDPN and familial pancreatic carcinoma: In another recent report, immunological depletion of CLEC-2 in mice using the anti-CLEC-2 mAb 2A2B10 suppressed haematogenous metastasis and thrombus formation of the PDPN-positive mouse melanoma cell B16F10, without inducing any significant bleeding.101 Further investigations are needed to evaluate therapies targeting PDPN in mitigating the thrombotic risk in pancreatic cancer.