Src activity is associated with many types of human cancer, including tumours of the colon, breast, pancreas, brain and skin.78 Hirayama et al.79 evaluated the PDPN expression in tumour samples obtained from 95 patients with invasive ductal carcinoma of the pancreas and found that PDPN expression in cancer-related fibrotic tissues was associated with a poor prognosis, especially in patients with large tumours or lymph node metastases. This evidence concerns the gene PDPN and colonic neoplasm.