F2RL1 and exocrine pancreatic carcinoma: Engagement of TF by FVIIa not only initiates the coagulation cascade but also activates protease-activated receptor 2 (PAR2) signalling after β1-integrin ligation, thereby contributing to angiogenesis, tumour cell proliferation and migration.35 Wojtukiewicz et al.36 showed substantial in situ TF expression in pancreatic carcinoma, along with other procoagulants, including prothrombin and fibrinogen.