TF and pancreatic adenocarcinoma: One study on 30 patients with pancreatic adenocarcinoma measured circulating TF-positive microvesicles both by flow-cytometry and by a functional procoagulant assay, and showed a slight reduction in the number of microvesicles with a significant reduction of microvesicle-TF procoagulant activity.59 Interestingly, higher numbers of circulating TF-positive microvesicles or microvesicle-TF activity correlated with TF expression and microvessel density on tumour tissues.