F2R and pancreatic neoplasm: Functional thrombin receptors have been identified in human pancreatic cancer cells but not in healthy pancreatic tissue.38 Aside from its procoagulant roles, thrombin enhances the adhesion of pancreatic adenocarcinoma cells to extracellular matrix proteins and to endothelial cells, suggesting that it is important for pancreatic tumour growth and invasion.7