Some pancreatic cancers express aberrantly glycosylated structures on their cell surface and shed large quantities of mucins into the circulation.45 Wahrenbrock and colleagues46 showed that injection of highly purified mucin into mice resulted in the rapid generation of platelet-rich microthrombi, and that thrombosis was markedly diminished in mice deficient in the mucin receptors, P-selectin or L-selectin. The gene discussed is MUC5AC; the disease is pancreatic neoplasm.