TF and Increased total leukocyte count: Several studies have reported that leukocytosis that accompanies cancer is associated with an increased risk of VTE.64 Apart from the capacity of monocytes/macrophages to express procoagulant TF and produce TF-positive microvesicles, highly activated neutrophils might enhance thrombosis by generating neutrophil extracellular traps (NETs).4 NETs are composed of extracellular DNA fibres, histones and granular proteins that have been shown to play a role in innate immunity by enhancing the proteolysis and killing of bacteria.