TF and familial pancreatic carcinoma: Pancreatic cancer, however, is characterised by the peculiarity of a high level of expression of TF in tumour tissue and the release of tumour-derived microvesicles that might promote distal thrombosis by activating both the extrinsic and intrinsic pathways, as well as by promoting platelet adhesion and activation, and the release of NETs from leukocytes.