ATG7 and cardiac hypertrophy: The anatomic results with or without HE staining show significant cardiac hypertrophy in the Atg7-deleted mice at age of 12 weeks, shown by representative images and coefficients of organ (mg/g) (Figure 2A); similar hypertrophy in other organs including lung and spleen was also apparent based on their elevated coefficients of organ (Figure 2B), mimicking the previous report that organ aging is characterized by the presence of hypertrophy [37].