For example, the cell cycle pathway that included inhibitors Cdkn3 and E2f8 was upregulated in Camk2n1−/− LV.26,27 Furthermore, Fabp4/FABP4 were downregulated in Camk2n1−/− LV and have been shown to promote cardiac hypertrophy in mice and regulate AMPK signaling, actin cytoskeleton, and oxidative phosphorylation,28 all of which were associated with Camk2n1 deletion in our study. Here, E2F8 is linked to cardiac hypertrophy.