Plasma insulin concentrations at t0 and t30–t60 minutes and area under the insulin curve following glucose bolus were significantly reduced together with homeostatic model assessment of insulin resistance (SHR, 1.22±0.06, Camk2n1−/−, 0.51±0.06, P=0.00001) in Camk2n1−/− compared with SHR (Figure 3A). This evidence concerns the gene INS and Insulin resistance.